The Collagen Receptor Discoidin Domain Receptor 2 Stabilizes Snail1 Protein to Facilitate Breast Cancer Metastasis

Increased stromal collagen deposition in human breast tumours correlates with metastases. We show that activation of the collagen I receptor DDR2 regulates Snail1 protein stability by stimulating ERK2 activity, in a Src-dependent manner. Activated ERK2 directly phosphorylates Snail1, leading to Snai...

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Detalhes bibliográficos
Main Authors: Zhang, Kun, Corsa, Callie A., Ponik, Suzanne M., Prior, Julie L., Piwnica-Worms, David, Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794710/
https://ncbi.nlm.nih.gov/pubmed/23644467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2743
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