Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy...

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Gepubliceerd in:N Engl J Med
Hoofdauteurs: Gerlinger, Marco, Rowan, Andrew J., Horswell, Stuart, Math, M., Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q., Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R., Nohadani, Mahrokh, Eklund, Aron C., Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878653/
https://ncbi.nlm.nih.gov/pubmed/22397650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113205
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