Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy...

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Detaylı Bibliyografya
Yayımlandı:N Engl J Med
Asıl Yazarlar: Gerlinger, Marco, Rowan, Andrew J., Horswell, Stuart, Math, M., Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q., Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R., Nohadani, Mahrokh, Eklund, Aron C., Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878653/
https://ncbi.nlm.nih.gov/pubmed/22397650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113205
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