Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:N Engl J Med
Prif Awduron: Gerlinger, Marco, Rowan, Andrew J., Horswell, Stuart, Math, M., Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q., Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R., Nohadani, Mahrokh, Eklund, Aron C., Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878653/
https://ncbi.nlm.nih.gov/pubmed/22397650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113205
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