Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy...

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Bibliografske podrobnosti
izdano v:N Engl J Med
Main Authors: Gerlinger, Marco, Rowan, Andrew J., Horswell, Stuart, Math, M., Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q., Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R., Nohadani, Mahrokh, Eklund, Aron C., Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878653/
https://ncbi.nlm.nih.gov/pubmed/22397650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113205
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