Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

BACKGROUND: Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS: To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy...

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Pubblicato in:N Engl J Med
Autori principali: Gerlinger, Marco, Rowan, Andrew J., Horswell, Stuart, Math, M., Larkin, James, Endesfelder, David, Gronroos, Eva, Martinez, Pierre, Matthews, Nicholas, Stewart, Aengus, Tarpey, Patrick, Varela, Ignacio, Phillimore, Benjamin, Begum, Sharmin, McDonald, Neil Q., Butler, Adam, Jones, David, Raine, Keiran, Latimer, Calli, Santos, Claudio R., Nohadani, Mahrokh, Eklund, Aron C., Spencer-Dene, Bradley, Clark, Graham, Pickering, Lisa, Stamp, Gordon, Gore, Martin, Szallasi, Zoltan, Downward, Julian, Futreal, P. Andrew, Swanton, Charles
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878653/
https://ncbi.nlm.nih.gov/pubmed/22397650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1113205
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