Novel Mutations in MLH1 and MSH2 Genes in Mexican Patients with Lynch Syndrome

Background. Lynch Syndrome (LS) is characterized by germline mutations in the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2. This syndrome is inherited in an autosomal dominant pattern and is characterized by early onset colorectal cancer (CRC) and extracolonic tumors. The aim of this s...

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Bibliographische Detailangaben
Veröffentlicht in:Gastroenterol Res Pract
Hauptverfasser: Moreno-Ortiz, Jose Miguel, Ayala-Madrigal, María de la Luz, Corona-Rivera, Jorge Román, Centeno-Flores, Manuel, Maciel-Gutiérrez, Víctor, Franco-Topete, Ramón Antonio, Armendáriz-Borunda, Juan, Hotchkiss, Erin, Pérez-Carbonell, Lucia, Rhees, Jennifer, Boland, Clement Richard, Gutiérrez-Angulo, Melva
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877485/
https://ncbi.nlm.nih.gov/pubmed/27247567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5278024
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