Mutant calreticulin-expressing cells induce monocyte hyperreactivity through a paracrine mechanism

Mutations in the calreticulin gene (CALR) were recently identified in approximately 70–80% of patients with JAK2-V617F-negative essential thrombocytosis and primary myelofibrosis. All frameshift mutations generate a recurring novel C-terminus. Here we provide evidence that mutant calreticulin does n...

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Publicado no:Am J Hematol
Principais autores: Garbati, Michael R., Welgan, Catherine A., Landefeld, Sally H., Newell, Laura F., Agarwal, Anupriya, Dunlap, Jennifer B., Chourasia, Tapan K., Lee, Hyunjung, Elferich, Johannes, Traer, Elie, Rattray, Rogan, Cascio, Michael J., Press, Richard D., Bagby, Grover C., Tyner, Jeffrey W., Druker, Brian J., Dao, Kim-Hien T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877170/
https://ncbi.nlm.nih.gov/pubmed/26573090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.24245
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