Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women

Recent large cohort studies revealed that healthy older individuals harbor somatic mutations that increase their risk for hematologic malignancy and all-cause cardiovascular deaths. The majority of these mutations are in chromatin and epigenetic regulatory genes (CERGs). CERGs play a key role in reg...

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Enregistré dans:
Détails bibliographiques
Publié dans:Exp Hematol
Auteurs principaux: Wiedmeier, J Erin, Kato, Catherine, Zhang, Zhenzhen, Lee, Hyunjung, Dunlap, Jennifer, Nutt, Eric, Rattray, Rogan, McKay, Sarah, Eide, Christopher, Press, Richard, Mori, Motomi, Druker, Brian, Dao, Kim-Hien
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993458/
https://ncbi.nlm.nih.gov/pubmed/27235757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.05.009
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