Clonal hematopoiesis as determined by the HUMARA assay is a marker for acquired mutations in epigenetic regulators in older women

Recent large cohort studies revealed that healthy older individuals harbor somatic mutations that increase their risk for hematologic malignancy and all-cause cardiovascular deaths. The majority of these mutations are in chromatin and epigenetic regulatory genes (CERGs). CERGs play a key role in reg...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Wiedmeier, J Erin, Kato, Catherine, Zhang, Zhenzhen, Lee, Hyunjung, Dunlap, Jennifer, Nutt, Eric, Rattray, Rogan, McKay, Sarah, Eide, Christopher, Press, Richard, Mori, Motomi, Druker, Brian, Dao, Kim-Hien
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993458/
https://ncbi.nlm.nih.gov/pubmed/27235757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.05.009
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