The ΔF508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Is Associated With Progressive Insulin Resistance and Decreased Functional β-Cell Mass in Mice

Cystic fibrosis (CF) is the result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). CF-related diabetes affects 50% of adult CF patients. How CFTR deficiency predisposes to diabetes is unknown. Herein, we examined the impact of the most frequent cftr mutation in humans...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Fontés, Ghislaine, Ghislain, Julien, Benterki, Isma, Zarrouki, Bader, Trudel, Dominique, Berthiaume, Yves, Poitout, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876763/
https://ncbi.nlm.nih.gov/pubmed/26283735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0810
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados