Antigen Nature and Complexity Influence Human Antibody Light Chain Usage and Specificity

Human antibodies consist of a heavy chain and one of two possible light chains, kappa (κ) or lambda (λ). Here we tested how these two possible light chains influence the overall antibody response to polysaccharide and protein antigens by measuring light chain usage in human monoclonal antibodies fro...

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Bibliografiska uppgifter
I publikationen:Vaccine
Huvudupphovsmän: Smith, Kenneth, Shah, Hemangi, Muther, Jennifer J., Duke, Angie L., Haley, Kathleen, James, Judith A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876604/
https://ncbi.nlm.nih.gov/pubmed/27113164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2016.04.040
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