Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen‐treated Asian breast cancer patients

AIM: The aim was to examine the influence of CYP2C19 variants and associated haplotypes on the disposition of tamoxifen and its metabolites, particularly norendoxifen (NorEND), in Asian patients with breast cancer. METHODS: Sixty‐six CYP2C19 polymorphisms were identified in healthy Asians (n = 240),...

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Bibliographic Details
Published in:Br J Clin Pharmacol
Main Authors: Lim, Joanne Siok Liu, Sutiman, Natalia, Muerdter, Thomas E., Singh, Onkar, Cheung, Yin Bun, Ng, Raymond Chee Hui, Yap, Yoon Sim, Wong, Nan Soon, Ang, Peter Cher Siang, Dent, Rebecca, Schroth, Werner, Schwab, Matthias, Chowbay, Balram
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
Subjects:
Pharmacogenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876188/
https://ncbi.nlm.nih.gov/pubmed/26799162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12886
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