Association of CYP2C19*2 and associated haplotypes with lower norendoxifen concentrations in tamoxifen‐treated Asian breast cancer patients

AIM: The aim was to examine the influence of CYP2C19 variants and associated haplotypes on the disposition of tamoxifen and its metabolites, particularly norendoxifen (NorEND), in Asian patients with breast cancer. METHODS: Sixty‐six CYP2C19 polymorphisms were identified in healthy Asians (n = 240),...

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Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: Lim, Joanne Siok Liu, Sutiman, Natalia, Muerdter, Thomas E., Singh, Onkar, Cheung, Yin Bun, Ng, Raymond Chee Hui, Yap, Yoon Sim, Wong, Nan Soon, Ang, Peter Cher Siang, Dent, Rebecca, Schroth, Werner, Schwab, Matthias, Chowbay, Balram
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
Schlagworte:
Pharmacogenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876188/
https://ncbi.nlm.nih.gov/pubmed/26799162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12886
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