Dose Reduction of Caspofungin in Intensive Care Unit Patients with Child Pugh B Will Result in Suboptimal Exposure

BACKGROUND AND OBJECTIVES: Caspofungin is an echinocandin antifungal agent used as first-line therapy for the treatment of invasive candidiasis. The maintenance dose is adapted to body weight (BW) or liver function (Child-Pugh score B or C). We aimed to study the pharmacokinetics of caspofungin and...

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Pubblicato in:Clin Pharmacokinet
Autori principali: Martial, Lisa C., Brüggemann, Roger J. M., Schouten, Jeroen A., van Leeuwen, Henk J., van Zanten, Arthur R., de Lange, Dylan W., Muilwijk, Eline W., Verweij, Paul E., Burger, David M., Aarnoutse, Rob E., Pickkers, Peter, Dorlo, Thomas P. C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2015
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875935/
https://ncbi.nlm.nih.gov/pubmed/26649870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0347-2
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