Dose Reduction of Caspofungin in Intensive Care Unit Patients with Child Pugh B Will Result in Suboptimal Exposure

BACKGROUND AND OBJECTIVES: Caspofungin is an echinocandin antifungal agent used as first-line therapy for the treatment of invasive candidiasis. The maintenance dose is adapted to body weight (BW) or liver function (Child-Pugh score B or C). We aimed to study the pharmacokinetics of caspofungin and...

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Detalhes bibliográficos
Publicado no:Clin Pharmacokinet
Main Authors: Martial, Lisa C., Brüggemann, Roger J. M., Schouten, Jeroen A., van Leeuwen, Henk J., van Zanten, Arthur R., de Lange, Dylan W., Muilwijk, Eline W., Verweij, Paul E., Burger, David M., Aarnoutse, Rob E., Pickkers, Peter, Dorlo, Thomas P. C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875935/
https://ncbi.nlm.nih.gov/pubmed/26649870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-015-0347-2
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