Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy

OBJECTIVE: Recombinant human leptin (metreleptin) improves glycemia and hypertriglyceridemia in patients with generalized lipodystrophy; antibody development with in vitro neutralizing activity has been reported. We aimed to characterize anti-metreleptin antibody development, including in vitro neut...

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Bibliographic Details
Published in:Clin Endocrinol (Oxf)
Main Authors: Chan, Jean L., Koda, Joy, Heilig, Joseph S., Cochran, Elaine K., Gorden, Phillip, Oral, Elif A., Brown, Rebecca J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875885/
https://ncbi.nlm.nih.gov/pubmed/26589105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cen.12980
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