In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection

BACKGROUND: The latent reservoir in resting CD4(+) T cells presents a major barrier to HIV cure. Latency-reversing agents are therefore being developed with the ultimate goal of disrupting the latent state, resulting in induction of HIV expression and clearance of infected cells. Histone deacetylase...

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Detalhes bibliográficos
Publicado no:Retrovirology
Main Authors: Tsai, Perry, Wu, Guoxin, Baker, Caroline E., Thayer, William O., Spagnuolo, Rae Ann, Sanchez, Rosa, Barrett, Stephanie, Howell, Bonnie, Margolis, David, Hazuda, Daria J., Archin, Nancie M., Garcia, J. Victor
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875645/
https://ncbi.nlm.nih.gov/pubmed/27206407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-016-0268-7
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