A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges

OBJECTIVES: Pre-exposure prophylaxis (PrEP) using antiretroviral drugs (ARVs) has been shown to reduce HIV transmission in people at high risk of HIV infection. Adherence to PrEP strongly correlates with the level of HIV protection. Long-acting injectable ARVs provide sustained systemic drug exposur...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Kovarova, Martina, Swanson, Michael D., Sanchez, Rosa I., Baker, Caroline E., Steve, Justin, Spagnuolo, Rae Ann, Howell, Bonnie J., Hazuda, Daria J., Garcia, J. Victor
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867102/
https://ncbi.nlm.nih.gov/pubmed/27002074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw042
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