A long-acting formulation of the integrase inhibitor raltegravir protects humanized BLT mice from repeated high-dose vaginal HIV challenges

OBJECTIVES: Pre-exposure prophylaxis (PrEP) using antiretroviral drugs (ARVs) has been shown to reduce HIV transmission in people at high risk of HIV infection. Adherence to PrEP strongly correlates with the level of HIV protection. Long-acting injectable ARVs provide sustained systemic drug exposur...

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Библиографические подробности
Опубликовано в: :J Antimicrob Chemother
Главные авторы: Kovarova, Martina, Swanson, Michael D., Sanchez, Rosa I., Baker, Caroline E., Steve, Justin, Spagnuolo, Rae Ann, Howell, Bonnie J., Hazuda, Daria J., Garcia, J. Victor
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867102/
https://ncbi.nlm.nih.gov/pubmed/27002074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw042
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