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HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways
Dimerization among the EGFR family of tyrosine kinase receptors leads to allosteric activation of the kinase domains of the partners. Unlike other members in the family, the kinase domain of HER3 lacks key amino acid residues for catalytic activity. As a result, HER3 is suggested to serve as an allo...
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| Pubblicato in: | Protein Cell |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Higher Education Press
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4875347/ https://ncbi.nlm.nih.gov/pubmed/22983903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-012-2065-y |
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