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HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways
Dimerization among the EGFR family of tyrosine kinase receptors leads to allosteric activation of the kinase domains of the partners. Unlike other members in the family, the kinase domain of HER3 lacks key amino acid residues for catalytic activity. As a result, HER3 is suggested to serve as an allo...
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| Publicado no: | Protein Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Higher Education Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4875347/ https://ncbi.nlm.nih.gov/pubmed/22983903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-012-2065-y |
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