Crystal structure of human Gadd45 reveals an active dimer

The human Gadd45 protein family plays critical roles in DNA repair, negative growth control, genomic stability, cell cycle checkpoints and apoptosis. Here we report the crystal structure of human Gadd45, revealing a unique dimer formed via a bundle of four parallel helices, involving the most conser...

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Bibliografiske detaljer
Udgivet i:Protein Cell
Main Authors: Zhang, Wenzheng, Fu, Sheng, Liu, Xuefeng, Zhao, Xuelian, Zhang, Wenchi, Peng, Wei, Wu, Congying, Li, Yuanyuan, Li, Xuemei, Bartlam, Mark, Zeng, Zong-Hao, Zhan, Qimin, Rao, Zihe
Format: Artigo
Sprog:Inglês
Udgivet: Higher Education Press 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875293/
https://ncbi.nlm.nih.gov/pubmed/22058036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-011-1090-6
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