ATXN7L3 AND ENY2 COORDINATE ACTIVITY OF MULTIPLE H2B DEUBIQUITINASES IMPORTANT FOR CELLULAR PROLIFERATION AND TUMOR GROWTH

Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene regulation. The deubiquitination module (DUBm) of the SAGA complex is a major regulator of global H2Bub1 levels, and components of this DUBm are linked to both neurodegenerative diseases and cancer. Unexpectedly, we find that abla...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Atanassov, Boyko S., Mohan, Ryan D., Lan, Xian Jiang, Kuang, Xianghong, Lu, Yue, Lin, Kevin, McIvor, Elizabeth, Li, Wenqian, Zhang, Ying, Florens, Laurence, Byrum, Stephanie D., Mackintosh, Samuel G., Davis, Tammy, Koutelou, Evangelia, Wang, Li, Tang, Dean, Tackett, Alan J., Washburn, Michael P., Workman, Jerry L., Dent, Sharon Y. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874879/
https://ncbi.nlm.nih.gov/pubmed/27132940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.030
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