ATXN7L3 AND ENY2 COORDINATE ACTIVITY OF MULTIPLE H2B DEUBIQUITINASES IMPORTANT FOR CELLULAR PROLIFERATION AND TUMOR GROWTH

Histone H2B monoubiquitination (H2Bub1) is centrally involved in gene regulation. The deubiquitination module (DUBm) of the SAGA complex is a major regulator of global H2Bub1 levels, and components of this DUBm are linked to both neurodegenerative diseases and cancer. Unexpectedly, we find that abla...

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Publicat a:Mol Cell
Autors principals: Atanassov, Boyko S., Mohan, Ryan D., Lan, Xian Jiang, Kuang, Xianghong, Lu, Yue, Lin, Kevin, McIvor, Elizabeth, Li, Wenqian, Zhang, Ying, Florens, Laurence, Byrum, Stephanie D., Mackintosh, Samuel G., Davis, Tammy, Koutelou, Evangelia, Wang, Li, Tang, Dean, Tackett, Alan J., Washburn, Michael P., Workman, Jerry L., Dent, Sharon Y. R.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874879/
https://ncbi.nlm.nih.gov/pubmed/27132940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.03.030
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