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Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas

Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. Whether these resistance mutations are having parallel effects on fitness across bacterial taxa, however, is unclear. Thi...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Biol Sci
Prif Awduron: Vogwill, T., Kojadinovic, M., MacLean, R. C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Royal Society 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874708/
https://ncbi.nlm.nih.gov/pubmed/27170722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rspb.2016.0151
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