Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

[Image: see text] BALB/c and Swiss mice are routinely used to validate the effectiveness of tuberculosis drug regimens, although these mouse strains fail to develop human-like pulmonary granulomas exhibiting caseous necrosis. Microenvironmental conditions within human granulomas may negatively impac...

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發表在:ACS Infect Dis
Main Authors: Irwin, Scott M., Prideaux, Brendan, Lyon, Edward R., Zimmerman, Matthew D., Brooks, Elizabeth J., Schrupp, Christopher A., Chen, Chao, Reichlen, Matthew J., Asay, Bryce C., Voskuil, Martin I., Nuermberger, Eric L., Andries, Koen, Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2016
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874602/
https://ncbi.nlm.nih.gov/pubmed/27227164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00127
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