Presence of multiple lesion types with vastly different microenvironments in C3HeB/FeJ mice following aerosol infection with Mycobacterium tuberculosis

Cost-effective animal models that accurately reflect the pathological progression of pulmonary tuberculosis are needed to screen and evaluate novel tuberculosis drugs and drug regimens. Pulmonary disease in humans is characterized by a number of heterogeneous lesion types that reflect differences in...

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Udgivet i:Dis Model Mech
Main Authors: Irwin, Scott M., Driver, Emily, Lyon, Edward, Schrupp, Christopher, Ryan, Gavin, Gonzalez-Juarrero, Mercedes, Basaraba, Randall J., Nuermberger, Eric L., Lenaerts, Anne J.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4457037/
https://ncbi.nlm.nih.gov/pubmed/26035867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019570
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