Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

[Image: see text] BALB/c and Swiss mice are routinely used to validate the effectiveness of tuberculosis drug regimens, although these mouse strains fail to develop human-like pulmonary granulomas exhibiting caseous necrosis. Microenvironmental conditions within human granulomas may negatively impac...

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書誌詳細
出版年:ACS Infect Dis
主要な著者: Irwin, Scott M., Prideaux, Brendan, Lyon, Edward R., Zimmerman, Matthew D., Brooks, Elizabeth J., Schrupp, Christopher A., Chen, Chao, Reichlen, Matthew J., Asay, Bryce C., Voskuil, Martin I., Nuermberger, Eric L., Andries, Koen, Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2016
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874602/
https://ncbi.nlm.nih.gov/pubmed/27227164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00127
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