Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

[Image: see text] BALB/c and Swiss mice are routinely used to validate the effectiveness of tuberculosis drug regimens, although these mouse strains fail to develop human-like pulmonary granulomas exhibiting caseous necrosis. Microenvironmental conditions within human granulomas may negatively impac...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Irwin, Scott M., Prideaux, Brendan, Lyon, Edward R., Zimmerman, Matthew D., Brooks, Elizabeth J., Schrupp, Christopher A., Chen, Chao, Reichlen, Matthew J., Asay, Bryce C., Voskuil, Martin I., Nuermberger, Eric L., Andries, Koen, Lyons, Michael A., Dartois, Véronique, Lenaerts, Anne J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874602/
https://ncbi.nlm.nih.gov/pubmed/27227164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00127
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