Evaluation of a Mouse Model of Necrotic Granuloma Formation Using C3HeB/FeJ Mice for Testing of Drugs against Mycobacterium tuberculosis

Persistence of Mycobacterium tuberculosis remains a significant challenge for the effective treatment of tuberculosis in humans. In animals that develop necrotic lung lesions following infection with M. tuberculosis, drug-tolerant bacilli are present and persist in an extracellular microenvironment...

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Main Authors: Driver, Emily R., Ryan, Gavin J., Hoff, Donald R., Irwin, Scott M., Basaraba, Randall J., Kramnik, Igor, Lenaerts, Anne J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Experimental Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370740/
https://ncbi.nlm.nih.gov/pubmed/22470120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00217-12
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