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Age-related Decline in Natural IgM Function: Diversification and Selection of the B-1a Cell Pool with Age

Streptococcus pneumoniae is the most common cause of pneumonia, which claims the lives of people over the age of 65 seven times more frequently than those aged 5–49. B-1a cells provide immediate and essential protection from S. pneumoniae through production of natural immunoglobulin, which has minim...

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Dades bibliogràfiques
Publicat a:J Immunol
Autors principals: Holodick, Nichol E., Vizconde, Teresa, Hopkins, Thomas J., Rothstein, Thomas L.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874569/
https://ncbi.nlm.nih.gov/pubmed/27183643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600073
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