Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis

RATIONALE: B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes (OSE) on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a, a...

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Publicat a:Circ Res
Autors principals: Upadhye, Aditi, Srikakulapu, Prasad, Gonen, Ayelet, Hendrikx, Sabrina, Perry, Heather M., Nguyen, Anh, McSkimming, Chantel, Marshall, Melissa A., Garmey, James C., Taylor, Angela M., Bender, Timothy P., Tsimikas, Sotirios, Holodick, Nichol E., Rothstein, Thomas L., Witztum, Joseph L., McNamara, Coleen A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830526/
https://ncbi.nlm.nih.gov/pubmed/31549940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315786
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