Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis

RATIONALE: B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes (OSE) on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a, a...

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Veröffentlicht in:Circ Res
Hauptverfasser: Upadhye, Aditi, Srikakulapu, Prasad, Gonen, Ayelet, Hendrikx, Sabrina, Perry, Heather M., Nguyen, Anh, McSkimming, Chantel, Marshall, Melissa A., Garmey, James C., Taylor, Angela M., Bender, Timothy P., Tsimikas, Sotirios, Holodick, Nichol E., Rothstein, Thomas L., Witztum, Joseph L., McNamara, Coleen A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830526/
https://ncbi.nlm.nih.gov/pubmed/31549940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315786
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