Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked To Human Coronary Atherosclerosis

RATIONALE: B-1 cell-derived natural IgM antibodies against oxidation-specific epitopes (OSE) on low-density lipoprotein are anti-inflammatory and atheroprotective. Bone marrow (BM) B-1a cells contribute abundantly to IgM production, yet the unique repertoire of IgM antibodies generated by BM B-1a, a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Circ Res
Egile Nagusiak: Upadhye, Aditi, Srikakulapu, Prasad, Gonen, Ayelet, Hendrikx, Sabrina, Perry, Heather M., Nguyen, Anh, McSkimming, Chantel, Marshall, Melissa A., Garmey, James C., Taylor, Angela M., Bender, Timothy P., Tsimikas, Sotirios, Holodick, Nichol E., Rothstein, Thomas L., Witztum, Joseph L., McNamara, Coleen A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830526/
https://ncbi.nlm.nih.gov/pubmed/31549940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315786
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