Protective role for B1b B cells and IgM in obesity-associated inflammation, glucose intolerance, and insulin resistance

OBJECTIVE: Little is known regarding the role(s) B cells play in obesity-induced metabolic dysfunction. The present study utilized a mouse with B cell-specific deletion of Id3 (Id3(Bcell KO)) to identify B cell functions involved in the metabolic consequences of obesity. APPROACH AND RESULTS: Diet-i...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Harmon, Daniel B., Srikakulapu, Prasad, Kaplan, Jennifer L., Oldham, Stephanie N., McSkimming, Chantel, Garmey, James, Perry, Heather M., Kirby, Jennifer L., Prohaska, Thomas A., Gonen, Ayelet, Hallowell, Peter, Schirmer, Bruce, Tsimikas, Sotirios, Taylor, Angela M., Witztum, Joseph L., McNamara, Coleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808436/
https://ncbi.nlm.nih.gov/pubmed/26868208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307166
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