Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1.

Loss of normal functions and gain of oncogenic functions when the p53 tumor suppressor gene is mutated are considered critical events in the development of the majority of human cancers. Human bronchial epithelial cells (BEAS-2B) provide an in vitro model system to study growth, differentiation, and...

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Detalhes bibliográficos
Main Authors: Gerwin, B I, Spillare, E, Forrester, K, Lehman, T A, Kispert, J, Welsh, J A, Pfeifer, A M, Lechner, J F, Baker, S J, Vogelstein, B
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC48742/
https://ncbi.nlm.nih.gov/pubmed/1557382
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