Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.

A previous study showed that the human insulin receptor (IR) could be activated by insertion of a 3' portion of the cDNA encoding the beta subunit into a retrovirus genome to form a Gag-IR fusion protein. While capable of transforming cells in culture, this IR cDNA-containing virus, called UIR, was...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Poon, B, Dixon, D, Ellis, L, Roth, R A, Rutter, W J, Wang, L H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1846965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.3.877
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