Molecular basis of the activation of the tumorigenic potential of Gag-insulin receptor chimeras.

A previous study showed that the human insulin receptor (IR) could be activated by insertion of a 3' portion of the cDNA encoding the beta subunit into a retrovirus genome to form a Gag-IR fusion protein. While capable of transforming cells in culture, this IR cDNA-containing virus, called UIR,...

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Bibliographic Details
Main Authors: Poon, B, Dixon, D, Ellis, L, Roth, R A, Rutter, W J, Wang, L H
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC50917/
https://ncbi.nlm.nih.gov/pubmed/1846965
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