Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

A protein-tyrosine-phosphatase (PTPase 1B; protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48), specific for phosphotyrosyl residues, was microinjected into Xenopus oocytes. This resulted in a 3- to 5-fold increase in PTPase activity over endogenous levels. The PTPase blocked the insulin-stimu...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Cicirelli, M F, Tonks, N K, Diltz, C D, Weiel, J E, Fischer, E H, Krebs, E G
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54355/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2164686/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.14.5514
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