Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.

A protein-tyrosine-phosphatase (PTPase 1B; protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48), specific for phosphotyrosyl residues, was microinjected into Xenopus oocytes. This resulted in a 3- to 5-fold increase in PTPase activity over endogenous levels. The PTPase blocked the insulin-stimu...

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Autori principali: Cicirelli, M F, Tonks, N K, Diltz, C D, Weiel, J E, Fischer, E H, Krebs, E G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1990
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC54355/
https://ncbi.nlm.nih.gov/pubmed/2164686
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