Structure of human Cdc45 and implications for CMG helicase function

Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. Here we report the 2.1-Å crystal structure of...

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Udgivet i:Nat Commun
Main Authors: Simon, Aline C., Sannino, Vincenzo, Costanzo, Vincenzo, Pellegrini, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873980/
https://ncbi.nlm.nih.gov/pubmed/27189187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11638
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