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Sld3CBD–Cdc45 structural insights into Cdc45 recruitment for CMG complex formation during DNA replication

DNA replication requires recruitment of Cdc45 and GINS into the MCM double hexamer by initiation factors to form an active helicase, the Cdc45–MCM–GINS (CMG) complex, at the replication origins. The initiation factor Sld3 is a central regulator of Cdc45 and GINS recruitment, working with Sld7 togeth...

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Principais autores: Hao Li, Izumi Ishizaki, Koji Kato, Xiaomei Sun, Sachiko Muramatsu, Hiroshi Itou, Toyoyuki Ose, Hiroyuki Araki, Min Yao
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications Ltd 2025-09-01
סדרה:eLife
נושאים:
DNA replication initiation
initiation factor Sld3
recruiting Cdc45
eukaryotes
budding yeast
גישה מקוונת:https://elifesciences.org/articles/101717
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