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Structure of human Cdc45 and implications for CMG helicase function
Cell division cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component of the Cdc45-MCM-GINS (CMG) helicase. Despite its essential biological function, its biochemical role in DNA replication has remained elusive. Here we report the 2.1-Å crystal structure of...
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| Publié dans: | Nat Commun |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4873980/ https://ncbi.nlm.nih.gov/pubmed/27189187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11638 |
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