Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites. Here we use zinc-finger nucleases to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 an...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Veiga, M. Isabel, Dhingra, Satish K., Henrich, Philipp P., Straimer, Judith, Gnädig, Nina, Uhlemann, Anne-Catrin, Martin, Rowena E., Lehane, Adele M., Fidock, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873939/
https://ncbi.nlm.nih.gov/pubmed/27189525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11553
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