Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer

BRCA1-associated RING domain protein 1 (BARD1) stabilizes BRCA1 protein by forming a heterodimeric RING-RING complex, and impacts function of BRCA1, including homologous recombination (HR) repair. Although colon cancer cells usually express wild type BRCA1, presence of an oncogenic BARD1 splice vari...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Ozden, Ozkan, Bishehsari, Faraz, Bauer, Jessica, Park, Seong-Hoon, Jana, Arundhati, Baik, Seung Hyun, Sporn, Judith C., Staudacher, Jonas J., Yazici, Cemal, Krett, Nancy, Jung, Barbara
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873788/
https://ncbi.nlm.nih.gov/pubmed/27197561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26273
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items