Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer

BRCA1-associated RING domain protein 1 (BARD1) stabilizes BRCA1 protein by forming a heterodimeric RING-RING complex, and impacts function of BRCA1, including homologous recombination (HR) repair. Although colon cancer cells usually express wild type BRCA1, presence of an oncogenic BARD1 splice vari...

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Publicado no:Sci Rep
Main Authors: Ozden, Ozkan, Bishehsari, Faraz, Bauer, Jessica, Park, Seong-Hoon, Jana, Arundhati, Baik, Seung Hyun, Sporn, Judith C., Staudacher, Jonas J., Yazici, Cemal, Krett, Nancy, Jung, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873788/
https://ncbi.nlm.nih.gov/pubmed/27197561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26273
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