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Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Opening and closing of the central ion-conducting pore in voltage-dependent ion channels is gated by changes in membrane potential. Although a gate residue in the eukaryotic voltage-gated sodium channel has been identified, the minimal molecular determinants of this gate region remain unknown. Here,...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Oelstrom, Kevin, Chanda, Baron
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873679/
https://ncbi.nlm.nih.gov/pubmed/27186888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11608
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