The ephrin-A1/EPHA2 signaling axis regulates glutamine metabolism in HER2-positive breast cancer

Dysregulation of receptor tyrosine kinases (RTKs) contributes to cellular transformation and cancer progression by disrupting key metabolic signaling pathways. The EPHA2 RTK is overexpressed in aggressive forms of breast cancer, including the HER2+ subtype, and correlates with poor prognosis. Howeve...

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Опубликовано в: :Cancer Res
Главные авторы: Youngblood, Victoria M., Kim, Laura C., Edwards, Deanna N., Hwang, Yoonha, Santapuram, Pranav R., Stirdivant, Steven M., Lu, Pengcheng, Ye, Fei, Brantley-Sieders, Dana M., Chen, Jin
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873477/
https://ncbi.nlm.nih.gov/pubmed/26833123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0847
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