Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC

Genome-wide analyses determined previously that the receptor tyrosine kinase (RTK) EPHA2 is commonly overexpressed in non–small cell lung cancers (NSCLCs). EPHA2 overexpression is associated with poor clinical outcomes; therefore, EPHA2 may represent a promising therapeutic target for patients with...

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Main Authors: Amato, Katherine R., Wang, Shan, Hastings, Andrew K., Youngblood, Victoria M., Santapuram, Pranav R., Chen, Haiying, Cates, Justin M., Colvin, Daniel C., Ye, Fei, Brantley-Sieders, Dana M., Cook, Rebecca S., Tan, Li, Gray, Nathanael S., Chen, Jin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001547/
https://ncbi.nlm.nih.gov/pubmed/24713656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72522
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