The ephrin-A1/EPHA2 signaling axis regulates glutamine metabolism in HER2-positive breast cancer

Dysregulation of receptor tyrosine kinases (RTKs) contributes to cellular transformation and cancer progression by disrupting key metabolic signaling pathways. The EPHA2 RTK is overexpressed in aggressive forms of breast cancer, including the HER2+ subtype, and correlates with poor prognosis. Howeve...

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Vydáno v:Cancer Res
Hlavní autoři: Youngblood, Victoria M., Kim, Laura C., Edwards, Deanna N., Hwang, Yoonha, Santapuram, Pranav R., Stirdivant, Steven M., Lu, Pengcheng, Ye, Fei, Brantley-Sieders, Dana M., Chen, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873477/
https://ncbi.nlm.nih.gov/pubmed/26833123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0847
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