Regulation of cancer glutamine metabolism by EphA2 RTK-dependent activation of transcriptional co-activators YAP and TAZ

Malignant tumors reprogram cellular metabolism to support cancer cell proliferation and survival. Although most cancers depend on a high rate of aerobic glycolysis, many cancer cells also display addiction to glutamine. Mounting evidence indicates key roles of glutamine transporters and glutaminase...

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Udgivet i:Sci Signal
Main Authors: Edwards, Deanna N., Ngwa, Verra M., Wang, Shan, Shiuan, Eileen, Brantley-Sieders, Dana, Kim, Laura C., Reynolds, Albert B., Chen, Jin
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819349/
https://ncbi.nlm.nih.gov/pubmed/29208682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan4667
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