The Bromodomain BET inhibitor JQ1 Suppresses Tumor Angiogenesis in Models of Childhood Sarcoma

The bromodomain and extra terminal domain (BET) inhibitor, JQ1 has marked antitumor activity against several hematologic malignancies as well as solid tumor models. Here we investigated its activity in vitro and in vivo against models of childhood rhabdomyosarcoma and Ewing sarcoma. In vitro, JQ1 (b...

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Udgivet i:Mol Cancer Ther
Main Authors: Bid, Hemant K., Phelps, Doris A., Xaio, Linlin, Guttridge, Denis C., Lin, Jiayuh, London, Cheryl, Baker, Laurence H., Mo, Xiaokui, Houghton, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873398/
https://ncbi.nlm.nih.gov/pubmed/26908627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0567
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