ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer’s disease has been reported. In this study, we examined the ef...

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Publicado en:PLoS One
Autores principales: Sano, Osamu, Tsujita, Maki, Shimizu, Yuji, Kato, Reiko, Kobayashi, Aya, Kioka, Noriyuki, Remaley, Alan T., Michikawa, Makoto, Ueda, Kazumitsu, Matsuo, Michinori
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872999/
https://ncbi.nlm.nih.gov/pubmed/27196068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155400
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