ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer’s disease has been reported. In this study, we examined the ef...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Sano, Osamu, Tsujita, Maki, Shimizu, Yuji, Kato, Reiko, Kobayashi, Aya, Kioka, Noriyuki, Remaley, Alan T., Michikawa, Makoto, Ueda, Kazumitsu, Matsuo, Michinori
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872999/
https://ncbi.nlm.nih.gov/pubmed/27196068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155400
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