ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production

ATP-binding cassette G1 (ABCG1) and ABCG4, expressed in neurons and glia in the central nervous system, mediate cholesterol efflux to lipid acceptors. The relationship between cholesterol level in the central nervous system and Alzheimer’s disease has been reported. In this study, we examined the ef...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sano, Osamu, Tsujita, Maki, Shimizu, Yuji, Kato, Reiko, Kobayashi, Aya, Kioka, Noriyuki, Remaley, Alan T., Michikawa, Makoto, Ueda, Kazumitsu, Matsuo, Michinori
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872999/
https://ncbi.nlm.nih.gov/pubmed/27196068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155400
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