Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes

AIMS: 3′,5′-Cyclic adenosine monophosphate (cAMP) signals in the heart are often confined to concentration microdomains shaped by cAMP diffusion and enzymatic degradation. While the importance of phosphodiesterases (degradative enzymes) in sculpting cAMP microdomains is well established in cardiomyo...

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書目詳細資料
發表在:Cardiovasc Res
Main Authors: Richards, Mark, Lomas, Oliver, Jalink, Kees, Ford, Kerrie L., Vaughan-Jones, Richard D., Lefkimmiatis, Konstantinos, Swietach, Pawel
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872880/
https://ncbi.nlm.nih.gov/pubmed/27089919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw080
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